A Thrombolysis Stroke is a blood clot blocking the blood supply to part of the brain. This clot can lead to some permanent damage. Six months after a stroke about half of all patients will still have disability, with some fatalities. Medicines like Alteplase are used in frontline treatment of thrombolysis stroke. These treatments improve blood supply to the brain and improve chances of a better recovery. Research suggests treatment has to be given as soon as possible and no later than 4./5hrs of onset of the stroke.
Benefits:
Reverse the effect
Reducesthe amount of disability
One person in ten or 10% treated with Alteplase will make a better recovery.
Alteplase appears to increase the number of people who are able to manage without help.
To confirm a stroke from a transient ischaemic attack (TIA) doctors follow a strict protocol listed below to determine which route to take:
Side effects
Serious side effects from a risk of bleeding from the first day after treatment.
Some bleeding risks are minor (EG: bleeding from injection site).
Most severe bleeding in the brain making the stroke worse.
Small number (3 in 100) will be fatal.
This bleeding can also occur naturally without receiving Alteplase.
Sudden onset of focal neurological deficit If subacute onset, look for typical syndrome Seizure (e.g. limb twitching) at onset makes ischaemic
stroke less likely but does occur. It is more common in intracerebral haemorrhage. Loss of consiousness is unusual in stroke. Look for signs of brainstem dysfunction. For diagnostic scores e.g. ROSIER
Ongoing symptoms and less than 3 hours from symptom onset? IF SO, STOP HERE, DO NOT GIVE ASPIRIN, and start THROMBOLYSIS PROTOCOL
NHS Fife Stroke Thrombolysis pathway & Protocol
There is an (in hours) and (out of hours) pathway in place.
Timescale starts when patient arrive with CT request in place within 5 mins of patient arrival. Ideally patient is in CT scanner 15mins after arrival, with 15 mins CT to treatment.
Patient assessed using the ROSIER guide and stroke team and CT advised.
ROSIER score is a measurement of consciousness, seizure activity, speech, weakness in the face, arm and leg. This is measured using a +1/0 scale. The score determines the likeliness of a stroke or Tran ischemic Attack (TIA).
Once a patient has agreed to Treatment, the clock is stopped at the onset of treatment. Optimal timescale is arrival to treatment within 30 minutes.
Treatment is done by IV bolus and infusion doses of Alteplase based on patient weight. Alteplase is a fibrinolytic drug that acts as thrombolytic by activating plasminogen to form plasmin, which degrades fibrin and so breaks up thrombi.(NICE guidelines).This is done over an hour and the patient monitored over the next 24hrs.
Overview
Strokes
9000 per year
1000 eligable for IV+PA injections
300 severe due to large artery occlusion
Intracranial stent
STEMI
cagnard LINNC 2015
Jeffery L Saver neurosurgeon – Rankin Scale (time of onset)
Aspect score
CT perfusion
Ineligible for TPA
Time from wake up – 76hr stroke
Time = brain quality
Role of the acute stroke is:
Exclude contraindications/haemorrhage
Establish diagnosis
Other pathologies SAH SDH Abscess
CT pitfalls
Inaccurate at early stages
Insensitive for small lesions
Insensitive for old bleeds
Insensitive for posterior fossa
However enough to exclude
Hyperacute 0-6hrs
Late 6-12hrs
Hyperdense artery sign
Insular ribbon sign
Odema takes hrs
CT fogging?????